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Symbol
Name
ID

Pax8
paired box 8
MGI:97492

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating T4 concentration	Elevated circulating thyroid-stimulating hormone concentration	Thyroid agenesis	Thyroid hypoplasia	Goiter	Ectopic thyroid	Hypothyroidism	Congenital hypothyroidism
Disease(s) Associated with PAX8
congenital nongoitrous hypothyroidism 2

Mouse Phenotypes

abnormal adenohypophysis morphology

decreased lactotroph cell number

decreased somatotroph cell number

increased thyrotroph cell number

abnormal thyroid gland morphology

abnormal thyroid follicle morphology

abnormal thyroid follicular cell morphology

absent thyroid follicular cells

abnormal thyroid gland development

abnormal thyroid diverticulum morphology

absent thyroid gland

small thyroid gland

decreased testis weight

testicular atrophy

decreased activity of thyroid gland

Availability

Mouse Genotype

Pax8^tm1(cre)Mbu/Pax8^tm1(cre)Mbu

Pax8^tm1Pgr/Pax8^tm1Pgr

Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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